This comprehensive text focuses on the systems approach to simulating and predicting pharmacokinetic behavior (including metabolism-based drug-drug interactions), in patient populations using demographic, physiological, and genetic information, as well as input from in vitro studies of drug absorption and disposition. "ADME" emphasizes the use of direct experimental in vitro data obtained from human material (microsomes, cells, tissue slices, recombinant proteins) supported with prediction of relevant parameters from physicochemical properties.

Key features include: