The International Conference on Intelligent Computing (ICIC) was formed to provide an annual forum dedicated to the emerging and challenging topics in artificial intel- gence, machine learning, pattern recognition, image processing, bioinformatics, and computational biology. It aims to bring together researchers and practitioners from both academia and industry to share ideas, problems, and solutions related to the m- tifaceted aspects of intelligent computing. ICIC 2010, held in Changsha, China, August 18–21, 2010, constituted the 6th - ternational Conference on Intelligent Computing. It built upon the success of ICIC 2009, ICIC 2008, ICIC 2007, ICIC 2006, and ICIC 2005, that were held in Ulsan, Korea, Shanghai, Qingdao, Kunming, and Hefei, China, respectively. This year, the conference concentrated mainly on the theories and methodologies as well as the emerging applications of intelligent computing. Its aim was to unify the picture of contemporary intelligent computing techniques as an integral concept that highlights the trends in advanced computational intelligence and bridges theoretical research with applications. Therefore, the theme for this conference was “Advanced Intelligent Computing Technology and Applications.” Papers focusing on this theme were solicited, addressing theories, methodologies, and applications in science and technology.