About the Book
Guide to the understanding and interpretation of Angio-OCT.
Provides complete overview of technique and interpretation, including terminology.
Describes use of OCT for diagnosis of ocular diseases and disorders in different parts of the eye, and future developments.
Highly illustrated with more than 250 clinical images.
Internationally recognised editor and author team comprising leading clinicians and researchers in ophthalmology and OCT imaging.
Useful for pathologists to understand the wide range of vascular pathologies discussed in this atlas.
Table of Contents: PART I: TECHNOLOGY AND INTERPRETATION
Section 1: Methods and Techniques of OCT Angiography Examination
1. Principles of Optical Coherence Tomography Angiography............................................................................ 3
David Huang, Yali Jia, Simon S Gao
OCT Angiography 3
Comparing Swept-Source and Spectral Optical Coherence Tomography 5
2. Interpretation of Optical Coherence Tomography Angiography.................................................................... 8
David Huang, Yali Jia, Simon S Gao
Anatomic Reference Planes and Angiographic Slabs 8
Angiovue Default Segmentation and Display 10
Recognizing Flow Projection Artifact and Nonvascular Flow Signal 10
Quantification: Flow Index and Vessel Density 10
Interpretation of Pathological Optical Coherence Tomography Angiography 11
3. Optical Coherence Tomography Angiography: Terminology........................................................................ 15
David Huang, Yali Jia, Simon S Gao
Structural Optical Coherence Tomography 15
Optical Coherence Tomography Angiography 15
Analysis of Optical Coherence Tomography Angiography 16
4. Techniques for Using OCT Angiography for Clinical Examination ............................................................... 17
Tony Ko, Jay Wei
The Angiovue OCT Angiography System 17
Principles of Operation 17
Vessels of the Deep Choroid 17
Acquisition Workflow 18
Understanding Motion Correction Technology (MCT) 18
Recognizing Artifacts in OCT Angiography 19
5. Clinical Applications of OCT SSADA Angiography in Everyday Clinical Practice....................................... 20
Bruno Lumbroso, Marco Rispoli, Maria Cristina Savastano
Inner Retina Disorders 20
Outer Retina Disorders 27
Section 2: OCT Angiography Examination of Structure and Histology
6. Retinal Normal Vascularization ........................................................................................................................... 32
Maria Cristina Savastano, Marco Rispoli, Bruno Lumbroso
Arteries and Retinal Veins 32
The Retinal Vascular Networks 32
Contents
xii Clinical OCT Angiography Atlas
PART II: OCT ANGIOGRAPHY STUDY OF DISEASES AND DISORDERS
Section 3: Anterior Segment OCT Angiography Examination
7. Corneal and Anterior Segment OCT Angiography .......................................................................................... 39
David Huang, Yan Li, Yali Jia
Anterior Segment OCT Angiography 39
Section 4: Retina OCT Angiography Examination: Age-related Macular Degenerations
8. OCT Angiography Examination of Choroidal Neovascular Membrane in
Exudative Age-related Macular Degeneration................................................................................................. 42
Ching J Chen, Min Wang, Royce Chen, Matthew Olson
Subtypes of Exudative AMD and Representative Cases 43
9. OCT Angiography Examination of Choroidal Neovascular Membrane in Other Disorders..................... 60
Maddalena Quaranta-El Maftouhi, Adil El Maftouhi
Type 1 CNV in Chronic Central Serous Chorioretinopathy 60
Polypoidal Choroidal Vasculopathy (PCV) 62
CNV in Pathologic Myopia 63
Angioid Streaks and Choroidal Neovascularization 63
CNV in Multifocal Choroiditis 63
Pseudovitelliform Reticular Dystrophy and CNV 67
10. OCT Angiography Follow-up of Choroidal Neovascularization After Treatment ...................................... 71
Bruno Lumbroso, Marco Rispoli
11. Non-neovascular Age-related Macular Degeneration.................................................................................... 75
Talisa de Carlo, Eric Moult, WooJhon Choi, Nadia K Waheed, Jay S Duker, James G Fujimoto
Early Stages 75
Late Stages 76
Section 5: Retina OCT Angiography Examination: Other Macular Diseases
12. OCT Angiography Findings in Central Serous Chorioretinopathy ............................................................... 89
Marco Bonini Filho, Talisa de Carlo, Eric M Moult, WooJhon Choi, James G Fujimoto, Jay S Duker, Nadia K Waheed
Description of Vascular Changes Using OCTA 90
Description of Nonvascular Changes Using OCTA 95
13. OCT Angiography Examination of Type 2 Idiopathic Macular Telangiectasia ........................................... 98
Ching J Chen, Matthew Olson, Royce Chen
14. OCT Angiography of Vascular Occlusions .......................................................................................................112
Marco Rispoli, Bruno Lumbroso, Maria Cristina Savastano
Retinal Vein Occlusions 112
Branch Vein Occlusion 114
Branch Artery Occlusion 116
15. Diabetic Retinopathy...........................................................................................................................................120
Talisa de Carlo, Eric M Moult, WooJhon Choi, Marco Bonini Filho, James G Fujimoto, Jay S Duker, Nadia K Waheed
Nonproliferative Diabetic Retinopathy 120
Ischemic Diabetic Maculopathy 123
Proliferative Diabetic Retinopathy 123
16. OCT Angiography in Diabetic Retinopathy.....................................................................................................132
André Romano, Rubens Belfort Jr
Optical Coherence Tomography Angiography Technique 132
Pre-proliferative Diabetic Retinopathy 132
Proliferative Diabetic Retinopathy 133
Contents xiii
17. OCT Angiography Examination of Foveal Avascular Zone...........................................................................137
Luca Di Antonio, Leonardo Mastropasqua
Section 6: Myopia and Pathologic Myopia
18. OCT Angiography Examination in High Myopia ............................................................................................142
Luca Di Antonio, Leonardo Mastropasqua
Section 7: Choroid
19. OCT Angiography Examination of Choroidal Nevi and Melanomas ..........................................................150
Gilda Cennamo
Pigmented Choroidal Lesions
Section 8: Glaucoma and Optic Nerve
20. OCT Angiography Examination in Glaucoma.................................................................................................156
David Huang, Michel Puech, Yali Jia, Simon S Gao, Liang Liu
Quantification of Peripapillary Retinal Flow Index and Vessel Density 156
Correlation Between Peripapillary Retinal OCT Angiogram, Nerve Fiber Map, and Visual Field 156
PART III: FUTURE DEVELOPMENTS IN OCT ANGIOGRAPHY
Section 9: Future Developments in OCT Angiography Examination
21. Ultrahigh Speed Swept Source Technology for OCT Angiography ............................................................161
Eric M Moult, WooJhon Choi, Nadia K Waheed, Talisa de Carlo, Jay S Duker, James G Fujimoto
SS-OCT for Ultrahigh Speed 161
Principles of OCTA 162
SS-OCTA of the Retinal Vasculature in Normal Eyes 163
SS-OCTA of the Choriocapillaris Vasculature in Normal Eyes 163
SS-OCTA in Patients with Diabetes 164
SS-OCTA in Patients with Non-exudative AMD 166
Index............................................................................................................................................................... 171