Competent experts provide a summary of the enormous progress achieved in the development of new detection methods of charged and neutral particles, and photons. These achievements were initiated by the advent of new particle colliders, e.g. the LHC at CERN but also by non-accelerator experiments. The present 2nd part of the handbook is devoted to the integration of detectors in large experiments, detectors for special applications, as well as the application of detectors in other fields like e.g. medicine, biology, applied physics and industry.