Quinolones remain one of the most important classes of antimicrobial agents discovered in recent years. Since the second edition of this best selling book in 1993, considerable advances have been made in the research on structure-activity relationships, mechanism of action, resistance, pharmacodynamics, and drug interactions. This new edition brings together in a single volume the current information on a larger number of compounds and their expanding clinical applications. All chapters have been extensively revised and updated to provide a knowledgeable summary of the problems and promises that quinolones hold for the scientific and clinical communities.