Step-Up is designed as a single-volume, concise yet comprehensive review book for 2nd year medical students preparing for the USMLE Step 1. This Second Edition addresses the new format of the USMLE Step 1 by incorporating a systems-based orientation, clinical integration of content, and expanded clinical cases. The book presents information in different ways in order to suit different learning styles. It includes material in bulleted, "high-yield" form, comprehensive illustrations and tables, clinical case studies, and "Quick Hits," or clinical "pearls" in the margin.